GESAMP Hazard Evaluation Procedure for Chemical Substances

On The Estimation of Hazard Potential for Chemical Substances

There is considerable interest in means for predicting reactivity hazard potential from chemical structure. Such means are intended to provide measures of the likelihood that a given chemical composition can undergo rapid self-reaction, i.e., that it can detonate or deflagrate. The means to be discussed are most useful in predicting behavior under unconfined conditions. As they are computationa...

Chemical “ Substances ” That Are Not “ Chemical Substances ”

The main scientific problems of chemical bonding were solved half a century ago, but adequate philosophical understanding of chemical combination is yet to be achieved. Chemists routinely use important terms (“element,” “atom,” “molecule,” “substance”) with more than one meaning. This can lead to misunderstandings. Eliminativists claim that what seems to be a baseball breaking a window is merel...

The evaluation of an analytical protocol for the determination of substances in waste for hazard classification.

The classification of waste as hazardous could soon be assessed in Europe using largely the hazard properties of its constituents, according to the the Classification, Labelling and Packaging (CLP) regulation. Comprehensive knowledge of the component constituents of a given waste will therefore be necessary. An analytical protocol for determining waste composition is proposed, which includes us...

Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification

Humans can be exposed to a panoply of agents and actions including chemicals, nanomaterials, metals, and complex mixtures. The link between these exposures and possible clinical sequelae including cancer is often poorly understood. Historically, regulators have addressed such uncertainty by applying linear lowdose defaults when establishing cancer risk estimates for suspected or known carcinoge...

Naming and Indexing of Chemical Substances for Chemical Abstracts